Nexium is a drug that reduces the production of hydrochloric acid by the glands of the stomach.
Due to the inhibition of secretory activity of the glands Nexium reduces gastric acidity and is used in treatment of various conditions associated with excessive secretion of hydrochloric acid (for example, gastroesophageal reflux disease, peptic ulcer of the stomach or duodenum, the disruption of the structure of the mucous membrane under the influence of drugs from the group of NSAIDs, Helicobacter pylori, etc.).
Form of issue, the names and composition of Nexium.
Currently Nexium is available in three dosage forms:
- Coated tablet 20 mg and 40 mg;
- Pellets (pellets) for solution preparation for oral administration of 10 mg;
- Lyophilisate for preparation of solution for intravenous administration at 40 mg.
That is, Nexium is available in two dosage forms for oral administration (tablets, pellets and granules) and one for intravenous administration. Most often the drug is used in pill form because it is the most convenient and familiar option. Although, in principle, pellets (pellets) – these are the same pills containing a lower dosage of the active substance. To understand how the insignificant difference between the two forms, you should know that pellets are pressed into small, flat particles of active and auxiliary substances of a drug, i.e., essentially – granules. In the pellets, these substances are free, but in tablets they are densely compressed.
The pellets are used less pills because they contain a lower dosage of the active substance, which is rather inconvenient. Pellets for solution for the reception inside is usually used either for children or for people who for whatever reason can’t swallow a pill.
Finally, the extract is Nexium used for preparation of solution for intravenous injection, which is used when you are unable to receive medications by mouth.
As active substances all dosage forms of Nexium contain esomeprazole at different dosages. So, tablets contain 20 mg or 40 mg of esomeprazole, pellets or granules, 10 mg, and valium is 40 mg in one bottle. In connection with such dosage many dosage forms in common parlance often referred to as the following terms “Nexium 40, Nexium 20, Nexium 10” or “Nexium powder“, in which the number indicates the amount of active substance. The term “Nexium powder” refers to pellets or pellets for solution for the reception inside. These names are not official but are very widely used because of their clarity and brevity.
Tablets of 20 mg and 40 mg are available in packs of 7, 14 and 28 pieces, pellets-granules in sachets of 10 mg of 10 or 28 pieces in a box lyophilisate and 10 vials. The pellets have the appearance of pale yellow or brownish granules of different size. The tablets have oblong shape and pink shell, one side of which is engraved “40 mG” or “20 mG” depending on the dose of esomeprazole, and on the reverse the letters “A/EI”. On the fault line of tablets have the appearance of a white field with yellow patches. Valium has the form of a compacted homogeneous mass of white color.
Pellets (pellets) and tablets Nexium as auxiliary substances contain the same following components:
- Methacrylic acid and ethyl acrylate copolymer;
- Magnesium stearate;
- Glycerol monostearate;
- Polysorbate 80;
- Iron oxide yellow;
- Dextrose (pellets);
- Polyplasdone (only tablets);
- Xanthan gum (tablet);
- Citric acid (tablets);
- Cellulose (pills);
- Paraffin wax (tablets);
- Macrogol (tablets);
- Sodium fumarate (tablet);
- Titanium dioxide (tablets).
Nexium lyophilisate for preparation of solution for intravenous administration as an auxiliary component contains only dinatria of edetate dehydrate and sodium hydroxide.