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In appointing the drug Lasix®, it is recommended to use the lowest dose sufficient to achieve the desired therapeutic effect. The drug is administered intravenously and, in exceptional cases, intramuscularly (intravenously or impossible when the application of the drug inside). Intravenous administration of the drug Lasix® is carried out only when taking the drug inside is not possible or there is malabsorption of the drug in the small intestine or if you need the extremely rapid effect. When using the intravenous administration of the drug Lasix® is always recommended as the early transfer of the patient to the oral pharmaceutical form Lasix®.

When administered intravenously, Lasix® should be injected slowly. The rate of intravenous administration should not exceed 4 mg per minute. In patients with severe renal insufficiency (serum creatinine >5 mg/DL), it is recommended that the speed of intravenous administration of the drug Lasix® did not exceed 2.5 mg per minute. To achieve optimal efficiency and suppression of counter-regulation (activation of the renin-angiotensin and anti-natriuretic links of neurohumoral regulation) is more preferable should be continuous infusion nutrients the introduction of the drug Lasix®, compared to patients with repeated intravenous administration of the drug. If after one or more bolus intravenous injections in acute conditions there is no possibility to conduct continuous intravenous infusion, the preferred is the introduction of low doses with short intervals between doses (approximately 4 hours) than intravenous bolus higher doses with large intervals between doses.

The solution for parenteral injection has a pH of about 9 and does not have buffer properties. At pH below 7 probably loss of active substance in the sediment, so dilution of the drug Lasix®, you must strive to make the pH of the resulting solution ranged from neutral to slightly alkaline. For breeding, you can use saline. The diluted solution of the drug Lasix® should be used as soon as possible. The maximum recommended daily dose for intravenous administration for adults is 1500 mg. In children, the recommended dose for parenteral administration is 1 mg/kg body weight (but not more than 20 mg per day). Duration of treatment determined by the doctor individually depending on indications.

Special considerations for dosing regimen in adults:
The recommended initial dose is 20-80 mg per day. The required dose is selected according to the diuretic response. It is recommended that the daily dose was administered for 2-3 times.

Swollen syndrome in acute heart failure.

The recommended initial dose is 20-40 mg administered as an intravenous bolus injection. The dose of the drug Lasix® may be adjusted depending on the therapeutic effect.

Swollen syndrome with chronic renal failure.

Natriuretic response to furosemide depends on a number of factors, including the severity of kidney failure, and sodium in the blood, so the effect of a dose cannot be precisely predicted. In patients with chronic renal failure requires careful selection of doses, by its gradual increase, so that fluid loss occurred gradually (at the beginning of the treatment fluid loss to approximately 2 kg of body weight per day).

In patients, on hemodialysis, usually supporting dose is 250-1500 mg/day.

When the intravenous dose of furosemide can be defined as follows: start treatment with an intravenous drip at a rate of 0.1 mg per minute and then gradually increased the speed every 30 minutes depending on the therapeutic effect.

Acute renal failure (to maintain excretion of fluid).

Before the beginning of treatment with Lasix® should be eliminated hypovolemia, arterial hypotension and significant electrolyte disorders and acid-base status. It is recommended that the patient as early as possible was transferred to the intravenous administration of the drug Lasix®on pills Lasix® (dose tablets Lasix® depends on the chosen intravenous dose). The recommended initial intravenous dose of 40 mg. If, after not achieving the desired diuretic effect, Lasix®can be administered as a continuous intravenous infusion, beginning with the introduction of speed, a component of 50-100 mg per hour.

Edema in nephrotic syndrome.

The recommended initial dose is 20-40 mg per day. The required dose is selected according to the diuretic response.

Swollen syndrome in diseases of the liver.

Furosemide is administered in addition to treatment with aldosterone antagonists in the case of their insufficient efficiency. To prevent the development of complications, such as violation of the orthostatic regulation of circulation or disturbance of electrolyte or acid-base status requires careful selection of dose so that fluid loss occurred gradually (at the beginning of the treatment fluid loss to approximately 0.5 kg of body weight per day). If intravenous administration is absolutely necessary, the initial dose for intravenous administration of 20-40 mg.

Hypertensive crisis, cerebral edema.

The recommended initial dose is 20-40 mg by intravenous bolus injection. The dose may be adjusted depending on the effect.

Maintaining forced diuresis in the case of poisoning.

The furosemide is administered after intravenous infusion of electrolyte solutions. The recommended initial dose for intravenous administration of 20-40 mg. The dose depends on the response to furosemide. Before and during treatment with the drug Lasix®should be monitored and to recover the loss of fluids and electrolytes.

Indications.

— swollen syndrome with chronic heart failure;
— swollen syndrome in acute heart failure;
— swollen syndrome with chronic renal failure;
— acute renal failure, including that during pregnancy and burns (to maintain the excretion of fluid);
— swollen syndrome nephrotic syndrome (nephrotic syndrome the first objective is the treatment of the underlying disease);
— swollen syndrome in diseases of the liver (if necessary in addition to the treatment with aldosterone antagonists);
— brain swelling.
— hypertensive crisis;
— maintaining forced diuresis in the case of poisoning with chemical compounds, displayed kidneys in an unmodified form.

Storage conditions.

List B. Store at temperatures not exceeding 25°C, protected from light. Keep out of reach of children. Shelf life – 3 years.

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