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The drug can help in Crohn’s disease, myasthenia gravisAzathioprine (Imuran). It is a powerful immunosuppressive agent for the individual. The synthesized drug was in 1959, and three years later it was applied in practice.
Azathioprine (Imuran) is used in the prevention of rejection reactions of the transportation of human organs. The drug can help in Crohn’s disease, myasthenia gravisAzathioprine (Imuran) is used in the prevention of rejection reactions of the transportation of human organs. The drug can help in Crohn’s disease, myasthenia gravis is a drug. It is a powerful immunosuppressive agent for the individual. The synthesized drug was in 1959, and three years later it was applied in practice.
The form of release of drug: tablet, film coated. Imuran has a cytotoxic and immunosuppressive effect on the body. The drug is well absorbed from the gastrointestinal tract. Is broken down in the body to form methyl nitramine and 6-mercaptopurine. Cmax has achieved already after a couple of hours. The drug produces a very high concentration in intestines, liver tissue.
Azathioprine is an immunosuppressant that suppresses the body’s defenses and inhibits cell division. At high doses inhibits the proliferation of granulocytes, and thus may cause leukopenia.
The Use Of Azathioprine.
This drug is used in the prevention of rejection reactions of the transportation of human organs. The tool is included in the combination therapy. Used in severe rheumatoid arthritis. Recommended in chronic active hepatitis, dermatomyositis, acquired hemolytic anemia, psoriasis.
The drug can help in Crohn’s disease, myasthenia gravis, Reiter’s syndrome, pyoderma gangrenosum and ulcerative colitis.
Contraindications of the drug.
Before this drug is prescribed, conduct the examination of the body. It can not be used in pregnancy and lactation and in children. Not recommended with hepatic insufficiency. If the medicine causes an allergic reaction, the treatment should be to finish. You can not drink the pills during the suppression of hematopoiesis (anemia, thrombocytopenia, lymphopenia).
Side effects of the drug.
Side effects from Imuran can be with different parties. So we have to consider all the options.
Possible allergic reaction to the drug, it will cause skin rash, drug fever, arthralgia. Possible megaloblastic erythropoiesis, macrocytosis, and bone marrow depression bleeding. From the blood should expect nausea, vomiting, loss of appetite, possible pain in the abdomen, the liver. People with transplanted organs may occur stomach ulcer, pancreatitis, intestinal bleeding, intestinal perforation, toxic hepatitis.
Some patients observed an acute renal failure, proveit, alopecia, meningeal reactions, teratogenicity, Carcinogenicity. Overdose drug threatens pancytopenia, hyperbilirubinemia, dyspeptic symptoms
The Dosage Of Azathioprine.
Take inside. Treatment should begin with high doses with a transplant is 5mg/kg. Daily dose ranges from 1 to 4 mg/kg If no contraindications in humans, the treatment can last for a long time.
Before the surgery follows week take 2-3 times 4mg/kg per day. After the surgery, the same dosage for 2 more months, then 2-3 mg/kg If symptoms of rejection of organs, increase the dose to 4mg/kg. Used drug for a long time. If a person has active hepatitis or rheumatoid arthritis, it is recommended to take the drug 1-2. 5 mg/kg / day. Then after some time reduce the dose to 0.5 mg/kg, but gradually. Psoriasis to consume 0.5 g 4 times a day, the duration of treatment to 48 days. Drug use the elderly is limited. Such patients should be consumed a minimum dosage of the drug.
Recommendations for use.
The result of the treatment can manifest itself in a couple of days or weeks. If within 3 months no results from medicines, it is necessary to conduct a series of tests. There is a risk of rejection of organs after cessation of treatment (even if treatment has been for several years).
Note: The first two months need to do weekly CBC to display the number of platelets. If you reduce them, lower the dose. If they are less than 3thousand. /MCL, the medication and recommend a blood transfusion.
A person should not be a long time in the sun regularly you need to go to a dermatologist. You should not self-medicate and to stop drinking the drug. Possible exacerbation of the situation. Store Imuran should be in a dark place at room temperature.
Azathioprine (Imuran) strong and effective immunosuppressive agent, which is indispensable in the operation and transplantation of human organs. When liver dysfunction reduces the dose of the drug.