The first thing to know about medication for rocaltrol approximate understanding of its purpose, the name of its active ingredient — calcitriol which is the active form of vitamin D.
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Vitamin D in food containing?
Vitamin D is contained in the following products:
- liver of marine fish;
- fatty fish such as salmon, herring, mackerel, tuna, perch and others;
- beef liver, pork;
- fatty meats, such as pork, duck, etc.;
- caviar fish;
- dairy Cream;
- sour Cream;
- vegetable oil;
- chanterelle mushrooms;
This substance promotes the absorption of calcium in the small intestine and is a substrate for bone mineralization. Once in the body, calcitriol “engages in battle” without additional activation of the hydroxylase of the kidney (which is required for calzidiola), in connection with what a pharmacological action develops almost from the first day of administration and lasts for another 3-5 days (for single dose).
The basis of therapeutic action of rocaltrol for osteoporosis is its ability, as a key element-a regulator of calcium metabolism, stimulate the activity of skeletal osteoblasts (osteoplastic cells). This drug can be used in a wide range of clinical situations. Thus, patients with marked impairment of renal function the production of calcitriol (occurs in the kidney the final, third stage of this process) is reduced or stops altogether, resulting in the formation of renal osteodystrophy. Salvation for these patients may be injected into the body of synthetic calcitriol (read: rocaltrol) from the outside. This drug normalizes the reduced absorption of calcium in the small intestine, leads the levels of alkaline phosphatase and parathyroid hormone in the blood to normal levels and, most importantly, removes hypocalcaemia. Rocaltrol to a certain extent relieves musculoskeletal pain and “rolls” back occurred by this time, pathological changes of bone tissue, associated with impaired mineralization (e.g., fibrous-cystic osteitis). In patients with postoperative or idiopathic hypofunction of the parathyroid glands rocaltrol makes the hypocalcaemia and its clinical signs are less pronounced.
In patients with D-dependent rickets (rickets that responds to treatment with vitamin D) rocaltrol used as a full Deputy of the natural metabolites of this vitamin. In patients suffering from D-resistant rickets (in which the introduction of outside even large doses of vitamin D does not give proper result), rocaltrol reduces tubular elimination of phosphates and in combination with phosphorous-containing drugs normalizes bone development.
Dosage form, which is produced rocaltrol — gelatin capsules. To start receiving the drug with the lowest daily dose 0.25 mcg. Selection of the optimum dose in each case is based on the content of calcium in the blood. Essential for the effectiveness of rocaltrol is the availability of enough calcium in the diet of the patient (for example, adults should get per day about 800 mg of food calcium). Sometimes justified the additional intake of calcium in the form of medicines. In any case an indicator of the patient’s condition and a starting point for planning and further adjustment of plan of pharmacotherapy and diet is the current level of calcium in serum. Given that rocaltrol improves the absorption of calcium in the intestine, supplementation of calcium may not be necessary. The maximum daily dose of calcium, based on all sources of receipt is 1000 mg. At first the level of calcium in the blood should be determined with a frequency not less than 2 times a week. After the selection of appropriate dose — 1 time per month. Important update: blood for the analysis it is recommended to take from “free”, don’t overtighten the tourniquet veins.