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Femara, is an antitumor drug. Provides antiestrogennoe act, selectively inhibits aromatase (an enzyme in estrogen synthesis) by highly specific competitive binding subunit of this enzyme – gem of cytochrome P450. Blocks the synthesis of estrogens in peripheral and tumor tissues.
Women in postmenopauzne period, the estrogens are formed mainly with the participation of the enzyme aromatase, which converts synthesized in the adrenal androgens (primarily Androstenedione and testosterone) to estrone and estradiol.
Daily intake of letrozole in a daily dose of 0.1-5 mg leads to a decrease in the concentration of estradiol, estrone and estrone sulfate in plasma at 75-95% of the original content. Suppression of the synthesis of estrogen is maintained throughout the treatment.
In applying the drug femara, in the dose range from 0.1 to 5 mg of a violation of the synthesis of steroid hormones in the adrenal glands is not observed, the ACTH test does not detect violations of the synthesis of aldosterone or cortisol. Additional supplementation of glucocorticoids and mineralocorticoids is required.
The blockade of estrogen biosynthesis does not lead to the accumulation of androgens, which are precursors of estrogen. In patients receiving Femara changes in concentrations of luteinizing and follicle stimulating hormones in the blood plasma, changes in thyroid function, changes in lipid profile, increased incidence of heart attacks and strokes have been reported.
The treatment of Famarol weakly increased frequency of osteoporosis (6.9% compared with 5.5% in the placebo group). However, the frequency of bone fractures in patients receiving the drug femara,, does not differ from that of healthy people of the same age.
Adjuvant therapy of Famarol early-stage breast cancer reduces the risk of progression, prolongs survival without signs of disease for 5 years, reduces the risk of developing another tumor of the breast.
Extended adjuvant therapy Famarol reduces the risk of progression by 42%. A significant advantage in survival without signs of disease in the group Femara was observed regardless of the involvement of the lymph nodes. Treatment with femara, the drug reduces mortality among patients with involvement of lymph nodes by 40%.

Indications for use.

Indications for use of the drug femara, are: early stage breast cancer, which cells have receptors for hormones, postmenopausal women, as adjuvant therapy; early breast cancer in postmenopausal women after standard adjuvant therapy with tamoxifen as extended adjuvant therapy; common forms of hormone-dependent breast cancer in postmenopausal women (first-line therapy); common forms of breast cancer among women postmenopause (natural or artificially induced) who received prior therapy with antiestrogens.

Contraindications.

Contraindications to the use of the drug femara, are: endocrine status, characteristic of the reproductive period; pregnancy; lactation (breastfeeding); childhood and adolescence till 18 years; hypersensitivity to letrozole or any component of the drug.
No data on the use of the drug femara, in patients with creatinine clearance less than 10 ml/min Before the appointment Femara such patients should carefully weigh the ratio between potential risk and expected effect of treatment.

Pregnancy.

Femara, the drug is contraindicated for use in pregnancy and lactation.
During therapy Famarol, given the potential for pregnancy, women in perimenopauznyj and early post-menopausal period should use reliable methods of contraception until stable post-menopausal hormone levels.

Additionally.

Patients with severely impaired liver function should be monitored.
Some of the side effects of the drug, such as weakness and dizziness may affect your ability to perform potentially hazardous activities, requiring concentration and quick reactions. In this regard, caution must be exercised in the management of vehicles and mechanisms.

Reviews about Femara.

-I started taking Femara after treatment of breast cancer. Fortunately, at the time asked, but still the treatment was serious. For me the choice was given several medications, as desired, but the doctor advised me all Aki to persuade your choice towards Temari. Said that this drug is better. But it costs more than others. But here already matter is not in money. The drug is hormonal, you need to watch the weight required if you are concerned about that this drug can be better. The drug is well tolerated, really good. Helps me.

-My aunt breast cancer. Was treated with antiestrogens, but it was no good. The doctor said that seriously counting on Femara on which he has good stats. I really statistics in medicine don’t like. Just remember the average temperature in the hospital and other revelations. But nowhere to go. The state running. Aunt and almost my age. Her to live and live and give birth to children. The first results are positive. Ultrasound shows a reduction of the shaded area.

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