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Periactin (Cyproheptadine hydrochloride) is an antagonist of histamine and serotonin receptors first generation. In the U.S., the drug most often prescribed to treat symptoms associated with allergies: hay fever, runny nose, eye irritation, hives and swelling. In addition, the drug approved by the FDA for the treatment of anaphylactic reactions caused by allergens, often as a complement to injections of adrenaline. The unique ability of the drug to improve appetite by its action on the inhibition of serotonin. This feature triggers a massive use of the drug not for its intended purpose, and as a means for weight gain, especially in patients suffering from reduced muscle mass associated with AIDS, cancer and other debilitating diseases.

Periactin has antihistaminic activity (blocks H1 receptors), but is a strong antiserotonin substance (reduces spasmogenic and other effects caused by serotonin). Also has anticholinergic activity. It has antiallergic action, and particularly effective in itching dermatoses (possibly due antiserotoninovogo action). The drug blocks hypersecretion of somatotropin in acromegaly and secretion of ACTH in Itsenko syndrome Cushing’s.

History Cyproheptadine hydrochloride.

Cyproheptadine hydrochloride is an antihistaminic drug, which is sold as a drug in most developed countries for decades. In 1961 the drug appear in the United States under the brand name Periactin® (Periactin) from Merck&Co. Under this brand of cyproheptadine hydrochloride was available in the US for many years, but in 2003 Merck&Co year voluntarily stops selling drug in the U.S. and Canada. Despite the fact that Merck Co stopped selling Periactin and in several other countries (probably because of low financial benefits), the brand is still available in over a dozen countries, including Australia, Austria, Belgium, Ireland, Italy, Netherlands, New Zealand, South Africa, Spain, Sweden, Thailand and the UK. It is also sold under numerous other brands around the world, in the form of both single and multi ingredient preparations. In both the U.S. and Canada is still available a certain amount of generic drug. After research cyproheptadine hydrochloride for long-term weight gain, in 1994 the world health organization acts as a warning against the use of the drug for this purpose. Despite this, many still take cyproheptadine hydrochloride as a short term appetite stimulant.

Dear doctors!

If you have experience with this drug to their patients share the result (leave a comment)! Did this cure the patient whether side effects during treatment? Your experience will be of interest to your colleagues and patients.

Dear patients!

If you have been given this medication and you have passed the course of therapy, tell me was it effective (did), were there side effects, what you liked/did not like. Thousands of people are searching for on the Internet reviews to different drugs. But only few of them leave. If you personally will not leave a review on this subject to read the rest will have nothing.

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