It competitively blocks H1-histamine receptors, has antiexudative, anti-allergic, anti-inflammatory, local anesthetic action. Reduces the permeability of capillaries, swelling of the mucous membranes, itching. Promethazine having adrenoliticheskoe, moderate peripheral and Central holinoliticheskoe effect.
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Inhibits histamine-N-methyltransferase, blocks Central histamine H3-receptors. Depresses the Central nervous system, has sedative, anxiolytic, antipsychotic and sedative effect, lowers the body temperature. Reduces the excitability of vestibular receptors, inhibits the function of the labyrinth, eliminates dizziness. Antiemetic effect due to blockade of receptors hemoretseptornoy zone oblong brain. In the appointment within 2 weeks before delivery may inhibit platelet aggregation in the newborn. In experimental studies have not found mutagenic effects and adverse effects on fetal development.
Rapidly and completely absorbed from the gastrointestinal tract. Ingestion effects are manifested through 15-60 minutes, with the/m introduction after 20 min, at/in 3-5 min Duration of action 4-6 h after ingestion up to 12 hours). Associated with blood plasma proteins at 65-90%. Metabolized in the liver and partially in the kidneys, with the formation of sulfoxides prometazina, N-demethylpromethazine and other derivatives. T1/2 is 7-14 hours write mainly with urine, including in the form of metabolites.
Application of the substance of Promethazine:
- exudative diathesis;
- rash and others.
Allergic skin reactions to drugs and chemicals:
- allergic conjunctivitis;
- allergic rhinitis;
- hay fever;
- the bites of wasps;
- serum sickness;
- false croup;
- asthmatic bronchitis;
- atopic bronchial asthma.
Anaphylactic and anaphylactoid reactions (in the complex therapy).
Rheumatism with the expressed allergic component:
- meniere’s syndrome;
- nausea and vomiting;
- the syndrome of motion sickness;
- neuroses and neurosis-like States;
- extrapyramidal disorders (in patients receiving neuroleptics);
- trigeminal neuralgia;
Premedication and the postoperative period as sedatives, for the artificial hibernation of potentiation of narcosis and local anesthesia), study of gastric secretion (when used as a stimulant of the secretion of histamine).