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Premarin: reviews, treatment, use, properties.

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International (International) name.
Estrogens conjugated
Synonyms (analogues).
Hormopleks Gormopleks drugs.
Mode. Regulate the development and safeguarding of the function of the female reproductive system, the formation of secondary sexual characteristics. Facilitate or cropped manifestations of menopause is vasomotor disorders, emotional (irritability, anxiety, depression) and urogenital (atrophic vaginitis, progressive diffuse atrophy of genital) symptoms. Prevent the development of postmenopauznogo osteoporosis, increase the level of HDL, lower-LDL cholesterol and total cholesterol, reduce the risk of cardiovascular diseases. Drug components are soluble in water and well absorbed in the intestine, penetrate into the target tissue (genitals, breasts, bones, the hypothalamus, the pituitary gland), cytoplasm and nucleus of cells, where it stimulates the synthesis of RNA and protein. Biotransformation occurs mainly in the liver, estrogens are excreted with jelchew, but reabsorbiruûtsâ from the intestine and portal vein system. Water-soluble conjugates of estrogens with acidic properties are ionized in the body and excreted kidneys with a minimum reabsorbciej in bone.

When appropriate.

menopause (hot flashes, night sweats, sleep disturbances, irritability, anxiety, depression, atrophic vaginitis, progressive diffuse atrophy of vulva), estrogenic failure during periods of menopause and postmenopause, post-menopausal osteoporosis, dysfunctional uterine bleeding, cardiovascular diseases during periods of menopause and postmenopause, hypogonadism in women, conditions after ovarioektomii, primary ovarian dysfunction, inoperable prostate cancer.

When not worth to apply.

Hypersensitivity, breast cancer or suspicion on him (except inoperable), estrogenzawisimae tumors, active thrombophlebitis or thromboembolic disease, kidney and liver disorders, sickle cell anemia, prolonged immobilization, Dubin-Johnson Syndrome and rotor, vaginal bleeding unclear etiology, pregnancy and breast-feeding.

Possible side effects.

depression, headache, increased body mass index, Endometrial hyperplasia, increased breast tenderness and predmenstrual′nopodobnyj syndrome, swelling, changes in the liver, jaundice, rashes and spots on the face, under the contact lens irritation, allergic contact reactions.Interaction.
acetylcholinesterase inhibitors reduce the effect, anticoagulants, antidepressants, protivodiabeticakih funds. Rifampicin, barbiturates, estrogen metabolism speed up butadion.

The application Method.

Inside. For cyclic applications is 0.625-1.25 mg\/day; intermittent therapy: daily 21 day with a break of 7 days, then continuous treatment day 1 time per day. When vasomotor symptoms-0.625 mg\/day, atrophic vaginitis and progressive diffuse atrophy of vulva-0.3-1.25 mg\/day, osteoporosis is 0.625 mg daily (permanently or intermittently). After ovarioektomii and in primary ovarian dysfunction is 1.25 mg\/day continuous or cycles, when gipogonadizme women 2.5-7.5 mg\/day for 20 days from 10-dnevnami interruptions, when dysfunctional uterine bleeding — by 3.75-7.5 mg\/day for 20 days (in the last 5-10 days, in combination with gestagenom). When neoperabel′nom breast cancer is 10 mg\/day for 3 months in neoperabel′nom prostate cancer-1.25-2.5 mg 3 times a day.
excess.

Specific recommendations for use.

with caution (under constant supervision) designate in diabetes, epilepsy, multiple sclerosis, mastopathy, tireotoxicose, porfiriâh. Prolonged use of estrogen may increase the risk of developing endometrial cancer; to reduce the risk of hyperplastic endometrial changes applied in combination with gestagenom with 10 to 14 day menstrual cycle.

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