Prednisolone is a synthetic glucocorticoid preparation. Available in several dosage forms: tablets, ointment and injections. It has anti-inflammatory, anti-allergic, immunosuppressive effect.
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Prednisolone tablets are prescribed for chronic and long-term inflammatory processes in the spine and joints, which are accompanied by severe pain.
The most commonly prescribed for chronic arthritis. Less often prescribed for chronic allergic diseases.
- bronchial asthma;
- allergic skin diseases (eczema, neurodermatitis, atopic dermatitis, contact dermatitis);
- chronic rhinitis.
In diseases associated with autoimmune reactions. Such diseases include rheumatoid arthritis, glomerulonephritis. Also appointed with scleroderma and lupus erythematosus.
Since Prednisolone is able to suppress tissue proliferation, it is used in the treatment of cancer. In addition, tablets can be prescribed as substitution therapy in the treatment of disorders of the adrenal glands.
Methods of application and doses of Prednisolone.
The dosage is set by the attending physician individually depending on the type and degree of the disease.
Adults in acute condition and as an introductory dose (on the first day) used 4-6 tablets during the day (daily dose 20-30 mg).
Then reduce to 1-2 tablets per day (5-10 mg).
For children, 1 mg per 1 kg of body per day is used. This dosage is divided into 4-6 receptions.
Stop taking it should gradually reducing the dose.
You can’t take Prednisolone when:
- individual intolerance;
- peptic ulcer of the stomach and duodenum;
- hypertensive disease;
- psychosis and depression;
- severe endocrine diseases;
- infectious process;
- diseases, frolic on the background of vaccination.
Application during pregnancy and breastfeeding.
Like all corticosteroids, prednisolone category C by the FDA.
This means that adequate and well-controlled studies of the safety of pregnant women have not been carried out.
The drug penetrates the placenta. There are proven teratogenic effects, possible development of adrenal insufficiency in the fetus and newborn.
Unfortunately, in some situations, corticosteroids have to be used to save the future mother. The decision on their appointment needs to be made by a doctor, informing the patient.
Nursing women are advised to stop breastfeeding for the duration of treatment.
Corticosteroids penetrate breast milk and can inhibit growth, the production of their own hormones and cause undesirable effects in the newborn.
Side effects of Prednisolone.
Side effects usually occur with long-term administration of Prednisolone at high doses.
The following side effects are possible:
- increased blood pressure;
- appearance of erosive-ulcerative lesions of the stomach and duodenum;
- vascular thrombosis; exacerbation of glaucoma and diabetes mellitus;
- the spread of infection bacterial, viral and fungal origin.
Occurs when long-term use of Prednisolone in high doses. Can be expressed by high blood pressure, peripheral edema. In addition, it is possible to increase the side effects.
Also, with prolonged use, Itsenko-Cushing’s syndrome may appear. Women may experience menstrual disorders and infertility. Men may have impotence. Children may slow their growth.
Reviews about Prednisolone.
With Prednisolone I have faced in 17 years. At this age, I was diagnosed with arthritis. I had swollen joints of my hands and knees. I was prescribed these pills, told to take 1 piece 8 times a day. Of the side effects were terrible appetite, and consequently weight gain, especially in the face area. But I immediately started to feel better, the pain and swelling are gone. After I stopped taking Prednisolone, I returned to normal appearance after about a year. Polyarthritis doesn’t bother me for 10 years.
My granddaughter has had allergies with terrible edema. She was admitted to hospital and prescribed among other drugs Prednisolone. During use, she increased appetite, but decreased immunity. Stop taking it abruptly can not be, you need to gradually reduce the dose. Gradually the negative effects are gone. But most importantly, this drug has helped the granddaughter to cope with allergies.
My daughter had atypical jaundice, which then added hepatitis. Atypical jaundice is when direct and indirect bilirubin is almost 50/50. It’s not normal. The treatment of this disease prescribe a corticosteroid, and refers to them Prednisolone. Got the pills on schedule, which was painted by a doctor, gradually reducing the dose. A month later, biochemical analysis showed that bilirubin is normal.