Nolvadex is a nonsteroidal antagonist of estrogen. Specifically binds to estrogenic receptors in peripheral and tumor tissues. Thus, eliminates the influence of estrogen produced in the body and stimulating the growth of cancer cells.
Slows down the progression of neoplastic process. After taking a single dose a few weeks retain the ability to block estrogen. Triggers ovulation in women,in men with oligospermia increases the level of LH and FSH.
Each year, the diagnosis “cancer” we hear more than 10 million patients worldwide. Fortunately, pharmaceutical companies are now ready to offer a large selection of quite effective anticancer agents. These include the drug Nolvadex is a tablet with active ingredient tamoxifen. Its principle is to block estrogen hormones that stimulate the development of tumors in target organs. The drug is designed by renowned international pharmaceutical group AstraZeneca.
Among the indications for receiving nolvadex for breast cancer in women and men, ovarian cancer and prostate cancer, soft tissue (melanoma, sarcoma), kidney cancer. In some cases, the drug is also prescribed for female infertility.
Manual Nolvadex is for reference only. Anticancer drugs are taken strictly under medical supervision. For each patient, prepared its own scheme of treatment, which depends on the extent of the disease and condition of the patient.
Standard prescribed dose of 20-40 mg of nolvadex 1-2 times a day, morning and evening. Tablets are swallowed whole, zabyvayutsya water. The drug is designed for continuous reception timing for each patient.
Contraindications. Nolvadex is prohibited to take during pregnancy and lactation. Tamoxifen with special care prescribed for thrombophlebitis, hypercalcemia, cataract and some other diseases.
Although Tamoxifen is used to treat and prevent recurrence of breast cancer since 1998, and currently can be considered the “gold standard” in the treatment of this disease. Nolvadex or its substitutes and today is used in Oncology, as evidenced by patient feedback, which for a long time is prescribed this drug.
“Removed the right breast, after a course of radiation therapy was prescribed Tamoxifen for 5 years.”
It has been proven that the effectiveness of the drug increases at long reception and it began to immediately appoint five years of admission. This reduces the mortality of patients after discontinuation of and prolong life for decades. Treatment with antagonists of estrogen to prevent the possibility of metastasis of the tumor. After this period, the oncologist evaluates the condition and makes conclusions: prolonged treatment add cytotoxic drugs or aromatase inhibitors.
According to some reports the drug is effective only in elderly women. After long-term administration of the drug observed adverse reactions reported by patients are: pain in the hip joints, weight gain, hair loss, varicose veins and thrombophlebitis, itching.
The drug may be administered prophylactically to prevent breast cancer in women who are predisposed to this disease. Obtained specific data that the drug reduces by one third the risk of developing breast cancer. However, discovered an unexpected side effect there is a risk of uterine sarcoma. On this question there are discussions and ongoing clinical trials. Assigning Tamoxifen for prophylaxis, the physician should discuss with the patient the benefits of the drug and a risk.